Original Adidas vintage coach jacket RSC Anderlecht 2005/06

RSC Anderlecht started the season as vice-champions. Trainer Franky Vercauteren saw strong players such as Aruna Dindane and Glen De Boeck disappear. De Boeck had decided to end his career after a serious injury. He became Vercauteren's assistant at Anderlecht.

But there were also many newcomers. Goalkeeper Silvio Proto was taken away from La Louvière and Bart Goor returned to the Astridpark after an absence of four years. The Argentinian striker Nicolás Frutos was also bought in the autumn period. However, he only became available for the club after the winter break. He took care of the departure of former top scorer Nenad Jestrović.

After the winter break, Anderlecht released midfielders Laurent Delorge and Marius Mitu. They were named in the Zheyun Ye bribery scandal. During their time at Lierse SK, they were allegedly bribed by members of the Chinese gambling mafia. When this news leaked after a television report, manager Herman Van Holsbeeck fired both players.

Anderlecht again finished the season as national champions despite strong competition from Standard Liège and Club Brugge. It was the club's 28th national title. It remained exciting until the end. With two matches left on the programme, Anderlecht won the highly charged top match against Standard at home. A week later, however, Anderlecht dropped points against AA Gent, meaning Anderlecht had to fight for the national title until the last matchday. Fortunately for Anderlecht, Ghent helped out, because the Buffaloes surprisingly won in Liège on the final day. Anderlecht itself gave the title celebration extra sparkle by winning 3-0 at home against Zulte Waregem. The title match also marked the farewell of captain Pär Zetterberg. At the same time, former Anderlecht player Gert Verheyen also ended his career as a professional footballer in Bruges.

Things went less smoothly in the Belgian Cup and Anderlecht were eliminated in the first match by second division team Verbroedering Geel.

The Purple & White qualified for the UEFA Champions League through the preliminary rounds. The Brussels club was not involved in the group stage. Anderlecht only took points for the first time on the last match day. Anderlecht finished last in the group and therefore could not survive the European winter.